The Effect of Two Low Doses of Aspirin on Whole Blood Thromboxane and Prostacyclin Generation in Healthy Subjects

Summary

The effects of two low doses of aspirin (20 mg and 100 mg) on prostacyclin and thromboxane formation during whole blood clotting were studied in 8 healthy volunteers.

A single 100 mg aspirin dose caused more than 90% reduction of both serum TXB₂ and 6-keto-PGF_1α; a single 20 mg dose of aspirin inhibited serum TXB₂ more than 6-keto-PGF_1α but effects on these two products could not be completely dissociated.

However, the effect of a single 20 mg aspirin dose on serum TXB₂, was of much longer duration than its inhibitory effect on PGI₂ synthesis during whole blood clotting.

Keywords

Thromboxane - Prostacyclin - Aspirin

• References

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